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The changes in the basic liver cadmium metabolism under adaptation to intravenous (i.v.) CdCl2 administration were studied in rats. The total liver level of metal remained unchanged. A marked redistribution of Cd was observed: there occurred the decrease in the level of labile and exchangeable Cd forms and the increase in the Cd sequestration. The increasing of the liver metallothionein (MT) level was noted. This reflects the first phase of MT induction, earlier than the decrease in the Cd level in the liver. The changes in Cd metabolism are considered as an adaptive response to excess Cd level in the body.Preliminary investigation of a protein-based oral spray.
For the first time, an oral spray loaded with bacteriocin is formulated. This formulation was based on the use of a new water-in-oil/oil-in-water emulsion, in combination with calcium phosphate nanoparticles for protection and controlled release of the peptide. The formulation showed good physical, chemical and microbiological stability and a good capacity to stabilize the bacteriocin after spray application. Bacteriocin loaded formulations were packed in containers of 2-5 ml volume and sterilized by using four different doses of gamma radiation (from 50 to 200 kGy) on the source packs. The levels of protection and sterilization after spraying were calculated. The effect of the process on bacteriocin activity was also evaluated. Use of the highest dose of gamma radiation (100 kGy) produced a significant protection of the spray and increased the activity of the bacterioc
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