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you have to have 8,379 votes in order to win and the deadline for voting is 12:00 PM EDT on October 9. This is the third question of the America’s Favorite Spoilers Quiz, and the answer is korea.High-resolution analysis of nucleotide polymorphisms in the human beta(A) globin gene cluster: implications for the evolution of the human beta(A) locus.
Comparative human genomic analyses have revealed differences in the number and organization of the beta(A) and beta(G) globin gene clusters among species. D(B)-like globin subregions have been found in mice and D(G)-like globin subregions in rabbits. The human genomic sequence shows that the human beta(A) and beta(G) clusters share a common organization with both the mouse and rabbit beta(A) gene clusters. In contrast, humans differ from both the mouse and rabbit by the presence of a novel beta(E)-like globin subregion between beta(A)- and beta(G) globin gene clusters. beta(A)- and beta(G) globin genes are largely collinear in the human genome and this gene organization has been conserved since the divergence of humans and chimpanzees approximately six million years ago. In this study, high-resolution restriction site analysis of the human beta(A)- and beta(G)-globin gene clusters has been used to map polymorphisms in the human beta(A) globin gene cluster. In addition, a PCR-based strategy was used to determine the number of allotypic variant globin genes within the beta(A)- and beta(G)-globin gene clusters in humans. Thirteen polymorphic sites were detected at the beta(A) locus and ten polymorphisms were found in the beta(G) locus. Eight polymorphic sites were located within the D-like subregions, and seven within the G-like region. The high resolution of the polymorphisms in the human beta(A) locus provides important insights into the evolution of this important gene complex. The finding of seven polymorphic sites in the G-like region in one human individual contrasts sharply with the absence of such
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