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Triggered prodrug liposomes: from design to anticancer therapy.
To review recent progress in the field of triggered prodrug liposomes in cancer therapy and their mechanism of action. Studies published between 2007 and 2012 on the subject were obtained from the MEDLINE database (via PubMed) and by manual review of relevant articles. Researchers have synthesized and studied amphiphilic lipids and their use as triggers for the release of drugs from liposomes. A fundamental first stage in the development of any drug delivery system, the achievement of controlled drug release, is achieved by liposomes that can remain stable for long periods in the circulation and then can undergo a controlled, energy-dependent release of drug due to the lipids in the bilayer interacting with cell membranes. Liposomes containing lipids that interact with membranes in a specific way have been developed to cause membrane damage, leading to the rapid release of drugs from the liposome. A sequence of recent studies has shown that a synthetic lipid (dioleoyl-glycerol-gamma-methylphosphorylethanolamine) could be used in liposomes as a trigger, causing the release of camptothecin (CPT), a potent anticancer drug that cannot be used in cancer treatment because of its toxicity and instability. Such liposomes were able to accumulate at the tumor site as a result of the low pH and released the drug at the tumor location. CPT-loaded liposomes could prove to be an effective delivery method for the treatment of localized tumors. Current studies of triggered prodrug liposomes are promising for future developments in the field of anticancer treatment.

वीवा एक दोस्त है असलिय क्या होगा वीवा को आजतक को परिणाम देने से अपने जीवन को चाहिए।.
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Feb 3, 2017
Language: HINDI 2chQuality : 480p BRRIp. Director: Sooraj R. Barjatya Stars: Shahid Kapoor, Amrita Rao, Anupam Kher.
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Movie Vivah. 2006 TV-14 2h 46m Bollywood Movies. Set up for an arranged marriage, a young couple enjoys an. Available to download. This movie is.
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Feb 3, 2017
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Vivah 2006 Hindi 480p HDRip 450mb. February 13, 2016 300MB Movies V. Movie Plot: After the passing away of his wife, wealthy Delhi-based .
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